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KMID : 0605620080150040303
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Journal of Korean Society of Biological Psychiatry
2008 Volume.15 No. 4 p.303 ~ p.309
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Association of the 5-HT5A Receptor Gene Polymorphisms and Citalopram Response in Korean Patients with Major Depressive Disorder
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Shim Jin-Hyun
Paik Jong-Woo
Oh Jeung-Woong
Kang Rhee-Hun
Lee Hwa-Young
Lee Min-Soo
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Abstract
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Objectives：Some reports have suggested that 5-HT5A polymorphism allelic association was associated with depression, however, there has been no report about relationship between the 5-HT5A gene and antidepressant response. We conducted the association study of the 5-HT5A receptor gene polymorphisms (-19G/C,12A/T) and response to citalopram in Korean patients with major depressive disorder(MDD).
Methods：A total of 106 patients with major depressive disorder were included in this study. The patient’s
symptoms were measured by 21-item Hamilton Depression Rating Scale(HAMD) at baseline, week 1, week 2, week 4 and week 8 during citalopram treatment. A Responder to citalopram was defined by 50% reduction of total HAMD scores. To analyze genetic polymorphisms, a polymerase chain reaction based method was used.
Results：At week 8, responders were 62, non-responders were 44. No significant differences of genotypes or allelic association in 19G/C and 12A/T polymorphisms were observed between responsive and non-responsive patients.
Conclusion：These results do not support the hypothesis that this polymorphism of the HT5A receptor gene is involved in the therapeutic response to citalopram.
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KEYWORD
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Depression, 5HT5A receptor, Polymorphism, Citalopram, Pharmacogenetics.
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